Ampligen®, currently under development by Hemispherx Biopharma in the US, acts. For comparison, a mixture of two nanoparticles, one with curcumin and the other with the platinum drug, was tested revealing a less noticeable synergistic effect compared to the co-delivery of both drugs in one drug carrier. Ampligen® polyI:pol圜12U is a mismatched double-stranded RNA that acts by inducing interferon production (immunomodulator) and by activating an intracellular enzyme (RNase-L) against viral RNA transcripts (antiviral). While curcumin and the platinum drug together without a carrier already showed synergy with a combination index ranging from 0.4 to 0.8, the combined delivery in one nanoparticle did enhance the synergistic effects resulting in a combination index of approximately 0.2-0.35. The results were analysed using the CalcuSyn software. Arzneim-ForschDrug Res 3: 285 Google Scholar. Loewe S (1953) The problem of synergism and antagonism of combined drugs. The toxicity of the dual drug delivery system was tested against the A2780 human ovarian cancer cell line and compared with the IC50 value of micelles that deliver either curcumin or the platinum drug alone. Chou T-C, Hayball M (1996) CalcuSyn for Windows: Multiple-drug dose-effect analyzer and manual.
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combination-index data generated by CalcuSyn software analyses. 123 CalcuSyn is a software tool whose main purpose is to aid individuals in analyzing mixed drug treatments, a more and more used practice in.
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The size of the dual drug micelles was measured to be 38 nm by DLS, which was confirmed by TEM. Calcusyn Crack Download Ultraviolet Full Movie In Hindi Dubbed 480p Download. The platinum(iv) drug oxoplatin was reacted with succinic anhydride to yield Pt(NH3)2Cl2, which acted as the drug and as a crosslinker for the stabilisation of micelles. Curcumin was incorporated into the self-assembled onion-type micelle by physical encapsulation into the PCL core with an entrapment capacity of 6 wt%.
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A triblock copolymer, based on the biodegradable polycaprolactone PCL, a PEG based shell and an amine bearing polymer as the interphase for the conjugation of platinum drugs was prepared by combination of ring-opening polymerization and RAFT polymerization. Combination indexes (CI) were calculated according to the method of Chou using CalcuSyn for Windows software as described elsewhere. Therefore, a micelle system with two different compartments, one for the drug curcumin and one for the conjugation of platinum drugs was designed. The aim of this work is to test whether the co-delivery of drugs within one nanoparticle can result in increased synergistic effects of both drugs.
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Combinational chemotherapy is often used to prevent drug induced resistance in cancer.